pH Hero® How It Works References

  1. Falagas ME. et al. (2006) Probiotics for prevention of recurrent urinary tract infections in women: a review of the evidence from microbiological and clinical studies. Drugs;66(9):1253-61.Probiotics for prevention of recurrent urinary tract infections in women: a review of the evidence from microbiological and clinical studies - PubMed (nih.gov)
  2. Coudray, MS. and Madhivanan P. (2020) Bacterial vaginosis-A brief synopsis of the literature. Eur J Obstet Gynecol Reprod Biol; 245:143-148.Bacterial Vaginosis - A Brief Synopsis of the Literature - PMC (nih.gov)
  3. Bautista CT, Wurapa EK and Sanchez JL. (2016) Brief report: Associations between antecedent bacterial vaginosis and incident chlamydia and gonorrhoea diagnosis, U.S. Army females, 2006–2012. MSMR. 2016;23(2):32–4.Brief report: Associations between antecedent bacterial vaginosis and incident chlamydia and gonorrhea diagnoses, U.S. Army females, 2006-2012 - PubMed (nih.gov)
  4. Van de Wijgert JH. et al. (2000) Intravaginal practises, vaginal flora disturbances and acquisition of sexually transmitted disease in Zimbabwean women. J Infect Dis; 181 (2):587-94.https://pubmed.ncbi.nlm.nih.gov/10669342/
  5. Grewal, K., Lee, Y.S., Smith, A. et al. (2022). Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation. BMC Med 20, https://doi.org/10.1186/s12916-021-02227-7
  6. Reid, G. et al. (2001) Probiotic lactobacillus dose required to restore and maintain a normal vaginal flora. FEMS Immunology & Medical Microbiology, 32 (1): p37-41. https://pubmed.ncbi.nlm.nih.gov/11750220/
  7. Keane, FE. Ison, CA. and Taylor-Robinson, D. (1997) A longitudinal study of the vaginal flora over a menstrual cycle. J. STD AIDS; 8(8), 489-494.A longitudinal study of the vaginal flora over a menstrual cycle - PubMed (nih.gov)
  8. Schwebke J.R. Richey C.M .and Weiss H.L. (1999) Correlation of behaviours with microbiological changes in vaginal flora. Infect. Dis.180, 1632–1636.Correlation of behaviors with microbiological changes in vaginal flora - PubMed (nih.gov)
  9. Ho Ming, et al. (2016) Oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 to reduce Group B Streptococcus colonization in pregnant women: A randomized controlled trial. Taiwanese Journal of Obstetrics & Gynecology. 55:515-518.https://pubmed.ncbi.nlm.nih.gov/27590374/
  10. Anukam K.C. et al., (2006) Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo-controlled trial. Microbes Infect. 8(6): 1450-4. (2).https://pubmed.ncbi.nlm.nih.gov/16697231/
  11. Morelli, L. et al. (2000) In vitro selection of probiotic lactobacilli: a critical appraisal. Curr Issues Intest Microbiol;1 (2):59-67. In vitro selection of probiotic lactobacilli: a critical appraisal - PubMed (nih.gov)
  12. Selis NN et al. (2021). Lactobacillus plantarum Lp62 exerts probiotic effects against Gardnerella vaginalis ATCC 49154 in bacterial vaginosis. Lett Appl Microbiol;73(5):579-589. Lactobacillus plantarum Lp62 exerts probiotic effects against Gardnerella vaginalis ATCC 49154 in bacterial vaginosis - PubMed (nih.gov)
  13. Erickson K. and Hubbard N. (2000) Probiotic immunomodulation in health and disease. Journal of Nutrition;130 (25suppl): S403 -S409 https://pubmed.ncbi.nlm.nih.gov/10721915/
  14. De Giani, A.et al. (2019) Identification of a bacteriocin-like compound from Lactobacillus plantarum with anti-microbial activity and effects on normal and cancerogenic human intestinal cells. AMB Express; 9:88. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579796/
  15. De Seta F., et al. (2014) Lactobacillus plantarum P17630 for preventing Candida vaginitis recurrence: A retrospective comparative study. Eur J Obstet Gynecol Reprod Biol; 182:136–9. Available from: http://dx.doi.org/10.1016/j.ejogrb.2014.09.018
  16. Wu, S. et al. (2022) The right bug in the right place: opportunities for bacterial vaginosis treatment. NPJ Biofilms Microbiomes;8(1):34.The right bug in the right place: opportunities for bacterial vaginosis treatment - PMC (nih.gov)
  17. Sirota, I. Zarek, SM. and Segars, JH. (2014) Potential Influence of the Microbiome on Infertility and Assisted Reproductive Technology. Semin Reprod Med ;32(1):35–42. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137456/pdf/nihms-618907.pdf
  18. Donders G.G. (2007) Definition and classification of abnormal vaginal flora. Best Pract. Res. Clin. Obstet. Gynaecol. 21:355–373. https://pubmed.ncbi.nlm.nih.gov/17434799/
  19. West Suffolk NHS foundation trust, Available from: https://www.wsh.nhs.uk/CMS-Documents/Services/Urology/Recurrent-UTI-Booklet.pdf [Accessed on 19th September 2023]
  20. NICE Guidelines (2023) Urinary Tract Infection (lower)-women: How common is it? Available from: https://cks.nice.org.uk/topics/urinary-tract-infection-lower-women/background-information/prevalence/ [Accessed on 19th September 2023]
  21. Vahedpoor Z. et al. (2021) Vaginal and oral use of probiotics as adjunctive therapy to fluconazole in patients with vulvovaginal candidiasis: A clinical trial on Iranian women. Curr Med Mycol;7(3):36-43. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006731/
  22. Martinez et al., (2009), ‘Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14’. Lett Appl Microbio., 48(3):269-74. https://pubmed.ncbi.nlm.nih.gov/19187507/
  23. Martinez RC et al. (2009) Improved cure of bacterial vaginosis with single dose of tinidazole (2 g), Lactobacillus rhamnosus GR-1, and Lactobacillus reuteri RC-14: a randomized, double-blind, placebo-controlled trial. Can J Microbiol;55(2):133-8. https://pubmed.ncbi.nlm.nih.gov/19295645/
  24. EFSA Botanical Health Claims. Available at: https://www.gov.uk/government/publications/on-hold-health-claims-on-foods
  25. Li, T.S. and Schroeder, W.R., (1996). Sea buckthorn (Hippophae rhamnoides L.): a multipurpose plant. HortTechnology, 6(4), pp.370-380.https://journals.ashs.org/horttech/view/journals/horttech/6/4/article-p370.xml#container-10126-item-10102
  26. Jasniewska, A and Diowksz, A. (2021) Wide spectrum of active compounds in sea buckthorn (Hippophae rhamnoides) for disease prevention and food production. Antioxidants (Basel); (8):1279.https://pubmed.ncbi.nlm.nih.gov/34439527/
  27. Larmo P.S. et al. (2014) Effects of sea buckthorn oil intake on vaginal atrophy in postmenopausal women: A randomized, double-blind, placebo-controlled study. Maturitas; 79:316–321.
  28. Guay, D.R.P. (2009) Cranberry and urinary tract infections. Drugs; 69 (7) :775-807.https://pubmed.ncbi.nlm.nih.gov/19441868/
  29. Stothers, L. et al. (2002) A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women. Can J Urol;9 (3):1558-62.https://pubmed.ncbi.nlm.nih.gov/12121581/
  30. Foo LY, Lu Y, Howell AB, Vorsa N. (2000) A-Type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli. J Nat Prod;63(9):1225-8https://pubmed.ncbi.nlm.nih.gov/11000024/
  31. Williams G, et al. (2023) Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev;4(4):CD001321.https://pubmed.ncbi.nlm.nih.gov/37068952/
  32. Wojnicz, D. et al. (2012) Medicinal plants extracts affect virulence factors expression and biofilm formation by the uropathogenic Escherichia coli. Urol Res;40(6):683-97. https://pubmed.ncbi.nlm.nih.gov/22915095/
  33. Anderson GG. et al. (2004) Intracellular bacterial communities of uropathogenic Escherichia coli in urinary tract pathogenesis. Trends Microbiol; 12:424–430.
  34. Mansour, A. et al. (2014) Efficient and Cost-Effective Alternative Treatment for Recurrent Urinary Tract Infections and Interstitial Cystitis in Women: A Two-Case Report. Hindawi Case Reports in Medicine, vol. 2014, Article ID 698758, 4 pages. https://www.hindawi.com/journals/crim/2014/698758/
  35. Lee, SJ. Et al. (1993) “Anti-inflammatory activity of naturally occurring flavone and flavonol glycosides,” Archives of Pharmacal Research, vol. 16, no. 1, pp. 25–28. https://link.springer.com/article/10.1007/BF02974123
  36. Petrolini FV. Et al (2013) Evaluation of the antibacterial potential of Petroselinum crispum and Rosmarinus officinalis against bacteria that cause urinary tract infections. Braz J Microbiol;44(3):829-34.https://pubmed.ncbi.nlm.nih.gov/24516424/
  37. Al-Yousofy F. et al. (2017) Parsley! Mechanism as antiurolithiasis remedy. Am J Clin Exp Urol;5(3):55-62.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698599/
  38. Gumaih H. et al. (2017) Evaluation of ethanolic seed extract of parsley on ethylene glycol induced calcium oxalate, experimental model. Int J Sci Res; 6:1683–1688.
  39. EFSA health and nutrition health claims. EUR-Lex - 02006R1924-20141213 - EN - EUR-Lex (europa.eu)