What are the causes of Restless Legs Syndrome? – DR.VEGAN
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Restless Legs Syndrome: Causes and how to manage it

Restless Legs Syndrome: Causes and how to manage it

Restless Legs Syndrome (RLS) is characterised by the overwhelming urge to move the legs.  Movement provides temporary relief from the unpleasant crawling or creeping sensation in the legs.  Here we explain what causes RLS, who is affected, and helpful vitamins for RLS. 

Some people describe the sensation like an itch you can’t scratch or like there’s fizzy water inside the legs.  For some, the symptoms of restless legs syndrome are mild and may come and go, while for others it can be constant and can prevent them getting sleep which can have a big impact on quality of life.  

What causes Restless Leg Syndrome (RLS)?

The cause of RLS is not 100% understood.  Some experts studying the nervous system believe the symptoms may be related to how the body deals with dopamine.  Dopamine is a chemical involved in controlling muscle movement and may be responsible for the involuntary leg movements associated with RLS.  For some people the cause may be genetic, especially if other family members also suffered from it. 

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Who is affected by RLS?

RLS is thought to affect 1 in 10 people in the UK. 

Women are twice as likely to experience restless legs syndrome than men, and around 1 in 5 women have restless legs when pregnant, particularly during the last trimester.

Menopause also seems to increase the occurrence and severity of RLS. It’s not clear why this is, but it’s thought that the changes in hormone levels such as oestrogen (rather than absolute levels of oestrogen) may be the cause of the symptoms.  Read our blog on the unusual symptoms of menopause

Vitamins for Restless Legs Syndrome


Iron helps with the actions of dopamine.  Interestingly, both Iron and dopamine levels dip in the evening and night – due to the body’s natural circadian rhythm (your internal body clock). 

Symptoms of RLS are often most notable in an evening or when trying to sleep.  Iron deficiency may be a cause of restless legs in some people.  If you think you may have low Iron, it may be useful to have your body’s Iron stores checked by your GP via a blood test. 


Magnesium is important for normal muscle function and getting adequate levels of Magnesium also supports your psychological wellbeing. 

Magnesium is often suggested for RLS based on anecdotal reports that it provides relief from the symptoms, particularly at night.  Some research suggests Magnesium supplementation may be useful for RLS among individuals who are deficient in Magnesium. 

Read our article How do I know if I'm deficient in Magnesium

A small clinical trial is currently being conducted to examine the effect of Magnesium supplementation in RLS and we will update this article when the results are published.

Vitamin D

There is thought to be an association between Vitamin D deficiency and RLS, however as yet only a few studies have explored this. 

Results from one study showed a Vitamin D supplement lessened the symptoms of RLS among people who were deficient in Vitamin D. 

Read our article on How do I know if I’m deficient in Vitamin D.

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How lifestyle can help RLS

There are some lifestyle changes you can make that may help with managing the symptoms of restless leg syndrome:

Regular activity

Try to keep active during the day and avoid sitting for long periods.  If you work at a desk most of the day, have regular breaks where you move and stretch your legs.  A walk in the evening and daily stretching will also be helpful.

Establish a good sleep routine

Stick to a regular bedtime routine at night and try to get out of bed at the same time each day.  A warm bath before bed or some relaxing yoga moves may be helpful.

Avoid smoking and alcohol

If you can't cut them out completely try to avoid these for several hours before going to bed. 

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