Brain Fuel® How It Works References

  1. Natural Remedies, BacoMind® l Bacopa Extracts For Brain & Cognition health (naturalremedieshumanhealth.com)
  2. Morgan and Stevens. (2010). Does Bacopa monnieri improve memory performance in older persons? Results of a randomised, placebo-controlled, double-blind trial. The Journal of Alternative and Complimentary Medicine; 16: 753-759.https://pubmed.ncbi.nlm.nih.gov/20590480/
  3. C. Barbhaiya et al. (2008) Efficacy and tolerability of BacoMind® on memory improvement in elderly participants- a double blind placebo -controlled study. Journal of Pharmacology and Toxicology; 3:425-434. https://www.researchgate.net/publication/247914285_Efficacy_and_Tolerability_of_BacoMindRon_Memory_Improvement_in_Elderly_Participants_-_A_Double_Blind_Placebo_Controlled_Study
  4. Usha et al. (2008) BacoMind®: A Cognitive enhancer in children requiring individual education programme. Journal of Pharmacology and Toxicology; 3(4): 302-310 https://www.researchgate.net/publication/269906354_BacoMindR_A_Cognitive_Enhancer_in_Children_Requiring_Individual_Education_Programme
  5. Dave et al. (2014). An open- label study to elucidate the effects of standardised Bacopa monnieri extract in the management of symptoms of attention-deficit hyperactivity disorder in children. Advances in Mind-Body Medicine; 28(2):10-5. https://pubmed.ncbi.nlm.nih.gov/24682000/ 
  6. Peth-Nui, T. et al. (2012) Effects of 12-week Bacopa monnieri consumption on attention, cognitive processing, working memory, and functions of both cholinergic and monoaminergic systems in healthy elderly volunteers. Evid Based Complement Alternat Med; 2012:606424. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537209/
  7. Kongkeaw, C. et al. (2014). Meta -analysis of randomised controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol; 151 (1) :528-35. https://www.sciencedirect.com/science/article/abs/pii/S0378874113008027?via%3Dihub
  8. Fatima U. et al. (2022) Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation. Front Nutr; 9:972379. https://pubmed.ncbi.nlm.nih.gov/36061899/
  9. NICE guidelines https://cks.nice.org.uk/topics/dementia/prescribing-information/acetylcholinesterase-inhibitors/ 
  10. Lorca, C. et al. (2022) Plant-derived nootropics and human cognition: A systematic review. Crit Rev Food Sci Nutr;1-25. https://pubmed.ncbi.nlm.nih.gov/34978226/#:~:text=The%20plant%20kingdom%20provides%20most%20of%20the%20currently,human%20cognition%20in%20conditions%20of%20health%20and%20disease.
  11. Malik, M. and Tlustos, P. (2023) Nootropic Herbs, Shrubs, and Trees as Potential Cognitive Enhancers. Plant (Basel);12 (6) :1364. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056569/
  12. Singh et al.(2019). Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders. Neurotherapeutics;16(3):666-674. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694352/
  13. Lee Lee KH, Cha M. and Lee BH. (2020) Neuroprotective Effect of Antioxidants in the Brain. Int J Mol Sci;21(19):7152. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582347/
  14. Singh SK, Srivastav S, Yadav AK, et al. (2016) Overview of Alzheimer’s disease and some therapeutic approaches targeting Aβ by using several synthetic and herbal compounds. Oxidative Med Cell Longev;2016: 7361613. https://pubmed.ncbi.nlm.nih.gov/27034741/
  15. Assi, AA. et al. (2023) Protective effects of curcumin and Gingko biloba extract in combination on a new model of Alzheimer’s disease. Inflammopharmacology;31 (3) :1449-1464. https://pubmed.ncbi.nlm.nih.gov/36856916/
  16.  Fan C-D.et al. (2017) Reversal of beta-amyloid-induced neurotoxicity in PC12 cells by curcumin, the important role of ROS-mediated signalling and ERK pathway. Cell Mol Neurobiol; 37:211–222. https://pubmed.ncbi.nlm.nih.gov/26971524/
  17.  Anand, P. et al. (2007). Bioavailability of curcumin: problems and promises. Mol Pharm;4(6):807-18 https://pubmed.ncbi.nlm.nih.gov/17999464/
  18. Cao, Y. et al (2021). Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins. Int J Mol Sci;22(23):12805. https://pubmed.ncbi.nlm.nih.gov/34884606/ The above is to help explain: Neurotoxins may damage the nervous system by inhibiting mitochondrial activity, increasing oxidative stress, increasing neuroinflammation, and up-regulating proteins related to cell death. https://pubmed.ncbi.nlm.nih.gov/29332042/
  19. Reddy PH. Et al. (2018) Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease. J Alzheimers Dis;61(3):843-866. https://pubmed.ncbi.nlm.nih.gov/29332042/
  20. Stackman RW.et al (2003) Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer’s disease by chronic Ginkgo biloba treatment. Exp Neurol; 184:510–520. https://pubmed.ncbi.nlm.nih.gov/14637120/
  21. Stough, C. et al. (2001) Neuropsychological changes after 30-day Ginkgo biloba administration in healthy participants. J. Neuropsychopharmacol.;4:131–134 https://pubmed.ncbi.nlm.nih.gov/11466162/
  22. Wang, Z. (2022). B vitamins and prevention of cognitive decline and incident dementia: systematic review and meta-analysis. Nutr Rev;80 (4):931-949.
  23. Hartwig-Savic, M. et al. (2023) A micronutrient supplement modulates homocysteine levels regardless of vitamin B biostatus in elderly subjects. Int J Vitam Nutr Res.2023, 30. https://pubmed.ncbi.nlm.nih.gov/36715360/
  24. Sangle P. et al. (2020) Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depression. Cureus;12(10): e11169 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688056/#:~:text=Some%20clinical%20studies%20have%20shown%20that%20higher%20Vitamin,Vitamin%20B12%20levels%20develop%20cognitive%20changes%20requiring%20treatment.
  25. Hintikka, J. et al. (2003) High vitamin B12 level and good treatment outcome may be associated in major depressive disorder;3:17.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC317314/
  26. Ma, X. et al. (2022) Phosphatidylserine, inflammation, and central nervous system diseases. Front Aging Neurosci; 14:975176. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382310/
  27. Schreiber S; et al. (2000). An open trial of plant-source derived phosphatidylserine for treatment of age-related cognitive decline. J. Psychiatry Relat. Sci. 37: 302–307. https://pubmed.ncbi.nlm.nih.gov/11201936/