8 most common questions about magnesium glycinate

Magnesium Glycinate has become one of the most popular forms of magnesium supplements for good reason. Known for its calming properties and gentle effect on digestion, it’s often used to support sleep, reduce stress, and ease muscle tension. But is it right for you? In this article, we answer the most common questions about magnesium glycinate, including its benefits, side effects, and the best time to take it.
What is magnesium glycinate and what does it do?
Magnesium glycinate is a highly bioavailable form of magnesium, meaning it's easily
absorbed and used by the body. It’s made by combining magnesium with the amino acid
glycine, which has naturally calming effects.
When you take magnesium glycinate, it helps:
- Support muscle relaxation
- Promote restful sleep
- Reduce symptoms of anxiety and stress
- Maintain healthy nerve and muscle function
Because of its gentle effect on the gut, it’s a preferred choice for people who experience
digestive issues with other forms of magnesium.
Magnesium

Benefits of magnesium glycinate
The benefits of magnesium glycinate extend beyond basic magnesium supplementation.
Some of the most notable include:
-
Better sleep quality: Helps calm the nervous system and supports deeper,
uninterrupted sleep. You may be interested in learning how your diet can impact your sleep. - Reduced anxiety and stress: Glycine promotes relaxation and reduces nervous system excitability. Discover foods and vitamins for stress.
- Muscle recovery and cramp relief: Supports muscle function and reduces spasms.
- Heart and metabolic health: Contributes to normal blood pressure and blood sugar control.
- Support during PMS: May reduce mood swings, cramps, and bloating. Explore nutrition advice for PMS.
These benefits make magnesium glycinate a go-to supplement for people dealing with stress, poor sleep, or muscle discomfort.
Are magnesium glycinate and magnesium bisglycinate the same?
Yes, magnesium glycinate and magnesium bisglycinate refer to the same compound. 'Bis'
indicates that magnesium is bound to two glycine molecules. Both names are used
interchangeably, and both offer the same absorption and benefits.
Is magnesium glycinate a sleeping pill?
No, magnesium glycinate is not a sleeping pill, but it can improve sleep naturally. It calms
the brain by supporting the production of GABA, a neurotransmitter that promotes relaxation. While it doesn’t cause sedation, it helps you fall asleep more easily and stay asleep longer.
When should I take magnesium glycinate: morning or night?
Many people ask when to take magnesium glycinate for the best effect. You can take it at any time of day, but for sleep and relaxation, taking it 1–2 hours before bed is ideal. For daytime stress or muscle support, you might prefer to take it in the morning or early afternoon. It is usually better to take it with food to help with the absorption.
Side effects of magnesium glycinate
Most people tolerate magnesium glycinate very well. Side effects of magnesium glycinate are extremely rare but may include:
- Mild stomach upset (mostly with high doses)
- Drowsiness (more common at bedtime doses)
- Nausea (if taken on an empty stomach)
Taking it with food can help minimise any discomfort.
Can magnesium glycinate cause weight gain?
No. Magnesium glycinate does not cause weight gain. In fact, magnesium helps regulate
insulin and may support healthy metabolism. If you notice weight changes, it’s likely related to other lifestyle or dietary factors.
Does magnesium glycinate cause constipation?
No, magnesium glycinate does not cause constipation. In fact, other types of
magnesium - like oxide - may have a laxative effect, but glycinate is known for being gentle on the digestive system.
Can magnesium glycinate cause insomnia or headaches?
No. Magnesium glycinate typically improves sleep, and it is sometimes used to help with
insomnia. It also does not cause headaches - in fact, magnesium is often used to help prevent
migraines.
Who should not take magnesium glycinate?
Magnesium glycinate is safe for most people; however, you should consult your doctor before taking it if you:
- Have kidney disease or impaired kidney function
- Take prescription medications, especially antibiotics, diuretics, or heart medications
- Are pregnant or breastfeeding (though magnesium is often needed during these times)
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